Authors: Rebecca L. Pfeiffer, James R. Anderson, Daniel P. Emrich, Jeebika Dahal, Crystal L. Sigulinsky, Jia-Hui Yang, Kevin D. Rapp, Carl B. Watt, Jessica C. Garcia, Mineo Kondo, Hiroko Terasaki, Robert E. Marc, and Bryan W. Jones.
Abstract: Ultrastructural connectomics has allowed for precise identification of neural network topologies in retina, exposing synaptic connectivity associated with specific pathways involved in neural retinal processing. In pathological degenerate retina such as retinitis pigmentosa (RP), retinal remodeling emerges as a phenomenon through a series of negative plasticity events originating from neural deafferentation initiated by photoreceptor degeneration. Early stages of remodeling include glial changes, GluR receptor alterations (reprogramming), and rewiring of retinal networks. The connectivities initiated by these processes are currently unknown. To address this problem, we have created an ultrastructural pathoconnnectome of early retinal remodeling in a rabbit model of retinitis pigmentosa, Retinal Pathoconnectome 1 (RPC1).