CRXO

The rod-cone crossover connectome of mammalian bipolar cells

Takeaway
All classes of cone bipolar cells use amacrine cell “C” motifs to inhibit rod bipolar cells.
Rod BCs use amacrine cell “R” motifs to inhibit all classes of cone bipolar cells.

Marc-JCN-CRXO-Fig-21-summary-boxes-revised-72dpi

Caption

Summary of rod-cone crossover motifs. Key: white rod BC, pale blue ON CBCs, dark blue OFF CBCs, pale red ON wide-field γACs, pale red double ring AI γACs, dark red OFF wide-field γACs, pale green ON narrow-field GACs, pale green double ring AII GACs, dark green OFF narrow-field GACs, resistors denote coupling, solid arrows are glutamate synapses, open arrows are GABA/glycine synaps- es. Gain n denotes glutamate steps starting from the photoreceptors and ignoring polarity; gain p denotes inhibitory steps; gain c denotes coupling.

Revised Manuscript submitted June 8, 2016 – accepted June 30, 2016
RET-JCN-16-0018-Marc-revised.pdf

Manuscript images and captions
RET-JCN-16-0018-Marc-Images-Captions-revised.pdf

Reviewer rebuttal
RET-JCN-16-0018-rebuttal.pdf

Supplemental Data
Download links (right or control-click)

CRXO.xml is a Viking Bookmark file of the cells reported in Rod-Cone Decision Networks.
Download it, launch Viking and RC1. Select the Bookmark Sidebar, right click, select “Import,”
navigate to CRXO.xml and open.

RC1-20160515-nw-ALL_hops_1.tlpx is a Tulip 4.8 file containing all nodes and edges of RC1
as of 2016.05.15. Download it, launch Tulip and load the tlpx.

RC1-CBa=null-YACAi-RodBC.txt a regex output query capturing all single instances of motifs C4 + C5. Download and view as text or import to spreadsheet.

Table_S1.pdf is a list of traced motifs in RC1.

Table_S2.pdf is a list of synaptic sizes for different motifs in RC1.

RC1 data figure PSD files
Marc-JCN-CRXO-Fig-04-CRXO-C1-300dpi.psd
Marc-JCN-CRXO-Fig-05-motif-C1-300dpi.psd
Marc-JCN-CRXO-Fig-06-motif-C2-300dpi.psd
Marc-JCN-CRXO-Fig-07-motif-C3-300dpi.psd
Marc-JCN-CRXO-Fig-08-motif-C4-300dpi.psd
Marc-JCN-CRXO-Fig-09-motif-C5-300dpi.psd
Marc-JCN-CRXO-Fig-10-motif-CR-300dpi.psd
Marc-JCN-CRXO-Fig-11-motif-R1-300dpi.psd
Marc-JCN-CRXO-Fig-12-motif-R2-300dpi.psd
Marc-JCN-CRXO-Fig-13-motif-R4-300dpi.psd
Marc-JCN-CRXO-Fig-14-motif-R5-300dpi.psd
Marc-JCN-CRXO-Fig-15-motif-R3-300dpi.psd
Marc-JCN-CRXO-Fig-16-motif-R25-300dpi.psd