We are pleased beyond measure to have successfully renewed our Retinal Remodeling R01, and look forward to a continued process of discovery in retinal plasticity of visually degenerate retina, this time with a connectomics angle.
Bryan W. Jones and Robert E. Marc and were selected as 2013 FASEB BioArt Winners (Press release here). This image shows a region of an amazingly complex retina from a goldfish (Carassius auratus auratus) analyzed using tools called Computational Molecular Phenotyping (CMP) that reveal the metabolic state of the all cell types in tissues. These cells were labeled with antibodies for the presence of two fundamental amino acid metabolites (anti-glycine in red, anti-GABA in blue) and an amino acid tracer of physiologic activity (anti-AGB in green). These labels allow us to visualize the metabolic state and therefore, classes of bipolar, amacrine and horizontal cells. More details on the image here.